A single-cell atlas of the normal and malformed human brain vasculature
Barrow Neurological Institute · University of California, San Francisco · +6 more institutions
Abstract
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity. By leveraging this reference, we investigated cellular and molecular perturbations in brain arteriovenous malformations, which are a leading cause of stroke in young people, and identified pathologic endothelial transformations with abnormal vascular patterning and the…
Citation impact
- FWCI
- 28.18
- Percentile
- 100%
- References
- 88
Authors
22- EAEthan A. WinklerCorresponding
Barrow Neurological Institute, University of California, San Francisco, Broad Center, Neurological Surgery
- CNChang N. KimCorresponding
University of California, San Francisco, Broad Center
- JRJayden Ross
University of California, San Francisco, Broad Center, Neurological Surgery
- JHJoseph H. Garcia
University of California, San Francisco, Neurological Surgery
- EGEugene Gil
University of California, San Francisco, Broad Center, Neurological Surgery
Topics & keywords
- Neuroscience
- Human brain
- Biology
- Immune system
- Transcriptome
- Inflammation
- Cell
- Stroke (engine)
- Good health and well-being