articleBrainJan 28, 2022HYBRID OA

How patients with multiple sclerosis acquire disability

FLFred LublinDADieter A. HäringHGHabib GanjgahiAOAlex OcampoFHFarhad Hatami

Icahn School of Medicine at Mount Sinai · Novartis (Switzerland) · +7 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Patients with multiple sclerosis acquire disability either through relapse-associated worsening (RAW) or progression independent of relapse activity (PIRA). This study addresses the relative contribution of relapses to disability worsening over the course of the disease, how early progression begins and the extent to which multiple sclerosis therapies delay disability accumulation. Using the Novartis-Oxford multiple sclerosis (NO.MS) data pool spanning all multiple sclerosis phenotypes and paediatric multiple sclerosis, we evaluated ∼200 000 Expanded Disability Status Scale (EDSS) transitions from >27 000 patients with ≤15 years follow-up. We analysed three datasets: (i) A full analysis dataset containing all…

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510
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65.53
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100%
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49
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Authors

14

Topics & keywords

Topics
Keywords
  • Medicine
  • Multiple sclerosis
  • Expanded Disability Status Scale
  • Hazard ratio
  • Clinical trial
  • Disease
  • Placebo
  • Physical therapy
UN Sustainable Development Goals
  • Good health and well-being
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