Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation of the intracellular STING protein triggers the production of a multifaceted array of immunostimulatory molecules, which, in the proper context, can drive dendritic cell maturation, antitumor macrophage polarization, T cell priming and activation, natural killer cell activation, vascular reprogramming, and/or cancer cell death, resulting in immune-mediated tumor elimination and generation of antitumor immune memory. Accordingly, there is a significant amount of ongoing preclinical and clinical research toward further understanding the role of the STING pathway in cancer immune…

• SG
  Susan G. Komen for the Cure

  Award: CCR19609205
• MR
  Melanoma Research Alliance

  Award: 503565
• SU
  Stand Up To Cancer

  Award: SU2C-AACR-IRG 20-17
• NC
  National Cancer Institute

  Award: R01 CA245134
• DO
  Division of Graduate Education

  Award: 1937963
• DO
  Division of Chemical, Bioengineering, Environmental, and Transport Systems

  Award: CBET-1554623
• DO
  Division of Molecular and Cellular Biosciences

  Award: 2036809
• CD
  Congressionally Directed Medical Research Programs

  Award: KC170091