Enhanced Chemodynamic Therapy by Cu–Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction
Seoul National University · Institute for Basic Science · +4 more institutions
Abstract
An urgent need in chemodynamic therapy (CDT) is to achieve high Fenton catalytic efficiency at small doses of CDT agents. However, simple general promotion of the Fenton reaction increases the risk of damaging normal cells along with the cancer cells. Therefore, a tailored strategy to selectively enhance the Fenton reactivity in tumors, for example, by taking advantage of the characteristics of the tumor microenvironment (TME), is in high demand. Herein, a heterogeneous CDT system based on copper–iron peroxide nanoparticles (CFp NPs) is designed for TME-mediated synergistic therapy. CFp NPs degrade under the mildly acidic conditions of TME, self-supply H2O2, and the released Cu and Fe ions, with their larger…
Citation impact
- FWCI
- 22.14
- Percentile
- 100%
- References
- 61
Authors
14- SKSagang Koo
Seoul National University, Institute for Basic Science
- OKOk Kyu Park
Seoul National University, Institute for Basic Science
- JKJonghoon Kim
Seoul National University, Institute for Basic Science
- SISang Ihn Han
Seoul National University, Institute for Basic Science
- TYTae Yong Yoo
Seoul National University, Institute for Basic Science
Topics & keywords
- Tumor microenvironment
- Fenton reaction
- Hydroxyl radical
- Catalysis
- Chemistry
- Tumor hypoxia
- In vivo
- Peroxide