Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives
Career Point University · Baba Ghulam Shah Badshah University · +6 more institutions
Abstract
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic antioxidants. An imbalance between the generation and neutralization of oxidants results in the progression to oxidative stress (OS), which in turn gives rise to various diseases, disorders and aging. The characteristics of aging include the progressive loss of function in tissues and organs. The theory of aging explains that age-related functional losses are due to accumulation of reactive oxygen species (ROS), their subsequent damages and tissue deformities. Moreover, the diseases and disorders caused by OS include cardiovascular diseases…
Citation impact
- FWCI
- 87.27
- Percentile
- 100%
- References
- 230
Authors
13Topics & keywords
- Oxidative stress
- Reactive oxygen species
- Antioxidant
- Enzyme
- Disease
- Reactive nitrogen species
- Endogeny
- Mechanism (biology)