Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology
Ministry of Education of the People's Republic of China · Anhui Medical University · +4 more institutions
Abstract
Abstract Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive ability. Exosomes derived from bone-marrow mesenchymal stem cells (BMSC-exos) are extracellular vesicles that can execute the function of bone-marrow mesenchymal stem cells (BMSCs). Given the versatile therapeutic potential of BMSC and BMSC-exos, especially their neuroprotective effect, the aim of this study was to investigate the potential effect of BMSC-exos on AD-like behavioral dysfunction in mice and explore the possible molecular mechanism. Methods BMSC-exos were extracted from the supernatant of cultured mouse BMSCs, which were isolated from the femur and tibia of adult C57BL/6…
Citation impact
- FWCI
- 19.32
- Percentile
- 100%
- References
- 64
Authors
7- SLSen Liu
Ministry of Education of the People's Republic of China, Anhui Medical University, Anhui Provincial Center for Disease Control and Prevention
- MFMin Fan
Ministry of Education of the People's Republic of China, Anhui Medical University, Anhui Provincial Center for Disease Control and Prevention
- JXJingxian Xu
Ministry of Education of the People's Republic of China, Anhui Medical University, Anhui Provincial Center for Disease Control and Prevention
- LYLongjun Yang
Anhui Medical University
- CQCongcong Qi
Fudan University
Topics & keywords
- Mesenchymal stem cell
- Microvesicles
- Neuropathology
- Bone marrow
- Neuroprotection
- Cognitive decline
- Stem cell
- Medicine
- Good health and well-being