The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation

Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even though LPS is well described for its role in the pathology of sepsis, considerable evidence demonstrates that LPS-induced signalling and immune dysregulation are also relevant in the pathophysiology of many diseases, characteristically where endotoxaemia is less severe. These diseases are typically chronic and progressive in nature and span broad classifications, including neurodegenerative, metabolic, and cardiovascular diseases. This Review reappraises the mechanisms of LPS-induced signalling and emphasises the crucial contribution of…

• SA
  South African Medical Research Council
• NN
  Novo Nordisk Fonden

  Award: NNF20CC0035580
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/L025752/1, BB/L025752/1