Bioactive Materials Promote Wound Healing through Modulation of Cell Behaviors

Skin wound repair is a multistage process involving multiple cellular and molecular interactions, which modulate the cell behaviors and dynamic remodeling of extracellular matrices to maximize regeneration and repair. Consequently, abnormalities in cell functions or pathways inevitably give rise to side effects, such as dysregulated inflammation, hyperplasia of nonmigratory epithelial cells, and lack of response to growth factors, which impedes angiogenesis and fibrosis. These issues may cause delayed wound healing or even non-healing states. Current clinical therapeutic approaches are predominantly dedicated to preventing infections and alleviating topical symptoms rather than addressing the modulation of…

• NN
  National Natural Science Foundation of China

  Awards: 52022095, 82071391, 51873207, 51973216, 51833010, and 51833010
• CA
  Chinese Academy of Sciences

  Award: 2019230
• PG
  People's Government of Jilin Province

  Award: 20200404182YY
• YI
  Youth Innovation Promotion Association of the Chinese Academy of Sciences

  Awards: No. 2019230, 2019230
• DO
  Department of Science and Technology of Jilin Province

  Award: 20200404182YY
• YI
  Youth Innovation Promotion Association
• PF
  Program for Jilin University Science and Technology Innovative Research Team

  Award: 20210509005RQ