articleJournal for ImmunoTherapy of CancerJan 1, 2022GOLD OA

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma

LYLei YangYHYun-Ting HeSDSong DongXWXue‐Wu WeiZCZhihong Chen

Cancer Institute (WIA) · Guangdong Academy of Medical Sciences · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Backgrounds Immunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the underlying mechanism. Being another important factor to affect the efficacy of immunotherapy, tumor microenvironment (TME) characteristics of this subgroup of NSCLC are not comprehensively understood up to date. Hence, we initiated this study to describe the specific TME of EGFR-mutant lung adenocarcinoma (LUAD) from cellular compositional and functional perspectives to better understand the immune landscape of this most common subtype of NSCLC. Methods We…

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Authors

13

Topics & keywords

Topics
Keywords
  • Immunotherapy
  • Cancer research
  • Epidermal growth factor receptor
  • Tumor microenvironment
  • CD8
  • Adenocarcinoma
  • Immune system
  • Lung cancer
UN Sustainable Development Goals
  • Good health and well-being
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