Data-informed discovery of hydrolytic nanozymes

Nanozyme is a collection of nanomaterials with enzyme-like activity but higher environmental tolerance and long-term stability than their natural counterparts. Improving the catalytic activity and expanding the category of nanozymes are prerequisites to complement or even supersede enzymes. However, the development of hydrolytic nanozymes is still challenged by diverse hydrolytic substrates and following complicated mechanisms. Here, two strategies are informed by data to screen and predict catalytic active sites of MOF (metal-organic framework) based hydrolytic nanozymes: (1) to increase the intrinsic activity by finely tuned Lewis acidity of the metal clusters; (2) to improve the density of active sites by…

• NN
  National Natural Science Foundation of China

  Awards: 21874067 and 21722503, 21722503, 21874067
• NU
  Nanjing University
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions
• FR
  Fundamental Research Funds for the Central Universities

  Award: 021314380195
• SS
  Sakura Science Exchange Program