Ghrelin
Helmholtz Zentrum München · Universidade de Santiago de Compostela · +44 more institutions
Abstract
BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward…
Citation impact
- FWCI
- 43.38
- Percentile
- 100%
- References
- 376
Authors
57- TDTimo D. MüllerCorresponding
Helmholtz Zentrum München
- RNRubén Nogueiras
Universidade de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago, Centro de Investigación Biomédica en Red
- MLMark L. Andermann
Beth Israel Deaconess Medical Center
- ZBZane B. Andrews
Monash University
- SDStefan D. Anker
Charité - Universitätsmedizin Berlin
Topics & keywords
- Ghrelin
- Endocrinology
- Internal medicine
- Medicine
- Biology
- Hormone
- Affordable and clean energy