Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook
Dalian University of Technology · Dalian University · +3 more institutions
Abstract
The discovery of a near-infrared (NIR, 650-900 nm) fluorescent chromophore hemicyanine dye with high structural tailorability is of great significance in the field of detection, bioimaging, and medical therapeutic applications. It exhibits many outstanding advantages including absorption and emission in the NIR region, tunable spectral properties, high photostability as well as a large Stokes shift. These properties are superior to those of conventional fluorogens, such as coumarin, fluorescein, naphthalimides, rhodamine, and cyanine. Researchers have made remarkable progress in developing activity-based multifunctional fluorescent probes based on hemicyanine skeletons for monitoring vital biomolecules in…
Citation impact
- FWCI
- 47.03
- Percentile
- 100%
- References
- 350
Authors
9Topics & keywords
- Fluorescence
- Photothermal therapy
- Biomolecule
- Photoacoustic imaging in biomedicine
- Nanotechnology
- Cyanine
- Rhodamine
- Rational design