Caloric restriction in humans reveals immunometabolic regulators of health span
Yale University · Washington University in St. Louis · +4 more institutions
Abstract
The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about 14% CR for 2 years in healthy humans improved thymopoiesis and was correlated with mobilization of intrathymic ectopic lipid. CR-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. Expression of the gene Pla2g7 encoding platelet activating factor acetyl hydrolase (PLA2G7) is inhibited in humans undergoing CR. Deletion of Pla2g7 in mice showed decreased thymic…
Citation impact
- FWCI
- 107.69
- Percentile
- 100%
- References
- 31
Authors
14Topics & keywords
- Inflammation
- Longevity
- Immune system
- Biology
- Mitochondrial biogenesis
- Immunology
- Adipose tissue
- Reprogramming