reviewBiomedicine & PharmacotherapyFeb 12, 2022GOLD OA

Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs

TZTing ZhuLWLei WangLWLiping WangQWQi Wan

Qingdao University · Qingdao Women and Children's Hospital · +1 more institution

Indexed incrossrefdoaj

Abstract

Neuroprotective and neurorestorative therapy represent two major drug intervention strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation, angiogenesis, and neurogenesis are the main pathological processes that underlie acute and chronic ischemic brain injury. Furthermore, their intimate interactions mediate blood-brain barrier permeability, increase neurovascular unit structural damage as well as a hemorrhagic transformation during ischemic stroke. We aimed to review the current understandings of the underlying mechanisms of neuroprotection and neurorestoration in ischemic stroke. Notably, traditional Chinese medicine (TCM) has notable advantages in the comprehensive treatment…

Citation impact

271
total citations
FWCI
20.41
Percentile
100%
References
207
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Neuroprotection
  • Excitotoxicity
  • Pharmacology
  • Neurogenesis
  • Medicine
  • Angiogenesis
  • Ischemia
  • Resveratrol
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding