reviewThe LancetJan 15, 2016DEGOLD OA

Schizophrenia

MJMichael J. OwenASAkira SawaPBPreben Bo Mortensen

Cardiff University · Johns Hopkins University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and…

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1,827
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100%
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Authors

3

Topics & keywords

Topics
Keywords
  • Schizophrenia (object-oriented programming)
  • Medicine
  • Psychiatry
  • Psychology
UN Sustainable Development Goals
  • Good health and well-being
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