Prussian Blue Nanozyme as a Pyroptosis Inhibitor Alleviates Neurodegeneration
Shanghai Jiao Tong University · Shanghai Sixth People's Hospital
Abstract
Current pharmacological interventions for Parkinson's disease (PD) remain unsatisfactory in clinical settings. Inflammasome-mediated pyroptosis represents a potential therapeutic target for the alleviation of neurodegenerative diseases. The development of inflammasome-mediated pyroptosis agonists or antagonists may transform the treatment of neurodegenerative diseases. However, the identification of specific compounds that inhibit pyroptosis remains challenging. Herein, Prussian blue nanozyme (PBzyme) is revealed as a pyroptosis inhibitor to alleviate the neurodegeneration in mouse and cell models of PD. PBzyme protects the microglia and neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).…
Citation impact
- FWCI
- 18.88
- Percentile
- 100%
- References
- 71
Authors
6- XMXinxin Ma
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- JHJunnian Hao
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- JWJianrong Wu
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- YLYuehua Li
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- XCXiaojun CaiCorresponding
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
Topics & keywords
- Pyroptosis
- Neurodegeneration
- Inflammasome
- MPTP
- Neuroprotection
- Neuroinflammation
- Microglia
- Neuroscience