articleJournal of the American Chemical SocietyFeb 16, 2022GREEN OA

Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia

SKShi KuangFWFangmian WeiJKJohannes KargesLKLibing KeKXKai Xiong

University of California San Diego · Centre National de la Recherche Scientifique · +3 more institutions

PubMed
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Abstract

Despite the clinical success of photodynamic therapy (PDT), the application of this medical technique is intrinsically limited by the low oxygen concentrations found in cancer tumors, hampering the production of therapeutically necessary singlet oxygen (1O2). To overcome this limitation, we report on a novel mitochondria-localized iridium(III) endoperoxide prodrug (2-O-IrAn), which, upon two-photon irradiation in NIR, synergistically releases a highly cytotoxic iridium(III) complex (2-IrAn), singlet oxygen, and an alkoxy radical. 2-O-IrAn was found to be highly (photo-)toxic in hypoxic tumor cells and multicellular tumor spheroids (MCTS) in the nanomolar range. To provide cancer selectivity and improve the…

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237
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100%
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Authors

9

Topics & keywords

Topics
Keywords
  • Singlet oxygen
  • Photodynamic therapy
  • Chemistry
  • Iridium
  • Prodrug
  • Photosensitizer
  • Reactive oxygen species
  • Mitochondrion
UN Sustainable Development Goals
  • Good health and well-being
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