Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines

Antibody responses are an important part of immunity after Coronavirus Disease 2019 (COVID-19) vaccination. However, antibody trajectories and the associated duration of protection after a second vaccine dose remain unclear. In this study, we investigated anti-spike IgG antibody responses and correlates of protection after second doses of ChAdOx1 or BNT162b2 vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United Kingdom general population. In 222,493 individuals, we found significant boosting of anti-spike IgG by the second doses of both vaccines in all ages and using different dosing intervals, including the 3-week interval for BNT162b2. After second vaccination, BNT162b2…

• SG
  Scottish Government
• LC
  Llywodraeth Cymru
• NI
  National Institute for Health Research Health Protection Research Unit

  Award: NIHR200915
• NI
  National Institute for Health and Care Research

  Award: NIHR200915
• DO
  Department of Health and Social Care
• UO
  University of Oxford

  Award: NIHR200915
• CS
  China Scholarship Council
• OU
  Oxford University Hospitals NHS Foundation Trust
• HF
  Huo Family Foundation
• MR
  Medical Research Council

  Awards: MC_UU_12023/22, MR/V001329/1, MC_UU_12023/22, COVID-19, MC_UU_00008/6
• NO
  NIHR Oxford Biomedical Research Centre

  Award: NIHR200915