Mechanical regulation of bone remodeling
Shanghai Jiao Tong University · Shanghai Sixth People's Hospital · +2 more institutions
Abstract
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts. These opposite processes allow the accommodation of bones to dynamic mechanical forces, altering bone mass in response to changing conditions. Mechanical forces are indispensable for bone homeostasis; skeletal formation, resorption, and adaptation are dependent on mechanical signals, and loss of mechanical stimulation can therefore significantly weaken the bone structure, causing disuse osteoporosis and increasing the risk of fracture. The exact mechanisms by which the body senses and transduces mechanical forces to regulate bone remodeling…
Citation impact
- FWCI
- 53.56
- Percentile
- 100%
- References
- 246
Authors
5- LWLijun WangCorresponding
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- XYXiuling You
Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences
- LZLingli Zhang
Shanghai Jiao Tong University, Center for Excellence in Molecular Cell Science, Shanghai Sixth People's Hospital, University of Chinese Academy of Sciences
- CZChangqing Zhang
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- WZWeiguo Zou
Center for Excellence in Molecular Cell Science, Shanghai Sixth People's Hospital, University of Chinese Academy of Sciences
Topics & keywords
- Bone remodeling
- Business
- Neuroscience
- Cell biology
- Medicine
- Internal medicine
- Biology