reviewJournal of Cachexia Sarcopenia and MuscleFeb 2, 2022GOLD OA

Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review

CLChun‐wei LiKYKang YuNSNg Shyh‐ChangZJZongmin JiangTLTaoyan Liu

Union Hospital · Chinese Academy of Medical Sciences & Peking Union Medical College · +12 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Age-associated obesity and muscle atrophy (sarcopenia) are intimately connected and are reciprocally regulated by adipose tissue and skeletal muscle dysfunction. During ageing, adipose inflammation leads to the redistribution of fat to the intra-abdominal area (visceral fat) and fatty infiltrations in skeletal muscles, resulting in decreased overall strength and functionality. Lipids and their derivatives accumulate both within and between muscle cells, inducing mitochondrial dysfunction, disturbing β-oxidation of fatty acids, and enhancing reactive oxygen species (ROS) production, leading to lipotoxicity and insulin resistance, as well as enhanced secretion of some pro-inflammatory cytokines. In turn, these…

Citation impact

564
total citations
FWCI
60.08
Percentile
100%
References
124
Citations per year

Authors

21

Topics & keywords

Topics
Keywords
  • Sarcopenia
  • Adipose tissue
  • Medicine
  • Insulin resistance
  • Lipotoxicity
  • Cachexia
  • Internal medicine
  • Sarcopenic obesity
UN Sustainable Development Goals
  • Good health and well-being
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