Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver‐Like Metabolic Biofactories
Utrecht University · University Medical Center Utrecht · +2 more institutions
Abstract
Organ- and tissue-level biological functions are intimately linked to microscale cell-cell interactions and to the overarching tissue architecture. Together, biofabrication and organoid technologies offer the unique potential to engineer multi-scale living constructs, with cellular microenvironments formed by stem cell self-assembled structures embedded in customizable bioprinted geometries. This study introduces the volumetric bioprinting of complex organoid-laden constructs, which capture key functions of the human liver. Volumetric bioprinting via optical tomography shapes organoid-laden gelatin hydrogels into complex centimeter-scale 3D structures in under 20 s. Optically tuned bioresins enable refractive…
Citation impact
- FWCI
- 18.71
- Percentile
- 100%
- References
- 78
Authors
17Topics & keywords
- Biofabrication
- Organoid
- Self-healing hydrogels
- 3D bioprinting
- Materials science
- Microscale chemistry
- Nanotechnology
- Microfluidics