Insights into N6-methyladenosine and programmed cell death in cancer

N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years. M6A plays multifunctional roles in normal and abnormal biological processes, and its role may vary greatly depending on the position of the m6A motif. Programmed cell death (PCD) includes apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, most of which involve the breakdown of the plasma membrane. Based on the implications of m6A methylation on PCD, the regulators and functional roles of m6A methylation were comprehensively studied and reported. In this review, we focus on the high-complexity links between m6A and…

• NN
  National Natural Science Foundation of China

  Awards: 81770107, 2019JJ20014, 2018YFA0107800, 81870105, 82003286, 81920108004, 82170138
• NS
  Natural Science Foundation of Hunan Province

  Awards: 2021JJ30022, 2019JJ20014
• NK
  National Key Research and Development Program of China

  Award: 2018YFA0107800