reviewJournal of Experimental & Clinical Cancer ResearchFeb 19, 2022GOLD OA

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

NKNisha KumariSHSeung Hong Choi

Seoul National University Hospital · Seoul National University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Cancer immunotherapy has emerged as a novel cancer treatment, although recent immunotherapy trials have produced suboptimal outcomes, with durable responses seen only in a small number of patients. The tumor microenvironment (TME) has been shown to be responsible for tumor immune escape and therapy failure. The vital component of the TME is tumor-associated macrophages (TAMs), which are usually associated with poor prognosis and drug resistance, including immunotherapies, and have emerged as promising targets for cancer immunotherapy. Recently, nanoparticles, because of their unique physicochemical characteristics, have emerged as crucial translational moieties in tackling tumor-promoting TAMs that amplify…

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326
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26.15
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100%
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205
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Authors

2

Topics & keywords

Topics
Keywords
  • Immunotherapy
  • Tumor microenvironment
  • Cancer immunotherapy
  • Immune system
  • Cancer
  • Cancer research
  • Medicine
  • Chimeric antigen receptor
UN Sustainable Development Goals
  • Good health and well-being
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