articleThe Journal of Experimental MedicineJan 4, 2022HYBRID OA

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

ECEszter CsászárNLNikolett LénártCCCsaba CserépZKZsuzsanna KörnyeiRFRebeka Fekete

Semmelweis University · HUN-REN Institute of Experimental Medicine · +6 more institutions

PubMed
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Abstract

Microglia, the main immunocompetent cells of the brain, regulate neuronal function, but their contribution to cerebral blood flow (CBF) regulation has remained elusive. Here, we identify microglia as important modulators of CBF both under physiological conditions and during hypoperfusion. Microglia establish direct, dynamic purinergic contacts with cells in the neurovascular unit that shape CBF in both mice and humans. Surprisingly, the absence of microglia or blockade of microglial P2Y12 receptor (P2Y12R) substantially impairs neurovascular coupling in mice, which is reiterated by chemogenetically induced microglial dysfunction associated with impaired ATP sensitivity. Hypercapnia induces rapid microglial…

Citation impact

262
total citations
FWCI
20.22
Percentile
100%
References
95
Citations per year

Authors

26

Topics & keywords

Topics
Keywords
  • Microglia
  • Purinergic receptor
  • Cerebral blood flow
  • Neuroscience
  • Vasodilation
  • Nitric oxide
  • Premovement neuronal activity
  • Adenosine
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