Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy  via  Type I PDT and PTT

Feng, Lina; Li, Chunbin; Liu, Lingxiu; Wang, Zhiyi; Chen, Zihan; Yu, Jia; Ji, Weiwei; Jiang, Guoyu; Zhang, Pengfei; Wang, Jianguo; Tang, Ben Zhong

doi:10.1021/acsnano.1c10019

articleACS NanoMar 1, 2022Closed access

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

LFLina Feng CLChunbin Li LLLingxiu Liu ZWZhiyi Wang ZCZihan Chen

Inner Mongolia University · Chinese Academy of Sciences · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy of acceptor planarization and donor rotation is proposed to design type I photosensitizers (PSs) and photothermal reagents. Acceptor planarization can not only enforce intramolecular charge transfer to redshift NIR absorption but also transfer the type of PSs from type II to type I photochemical pathways. Donor rotation optimizes photothermal conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, and 2TPEVDPP, with different number of rotors were…

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Topics & keywords

Topics

Keywords

Photodynamic therapy
Photothermal therapy
Acceptor
Chemical-mechanical planarization
Materials science
Reagent
Photochemistry
Intramolecular force

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