reviewFrontiers in ImmunologyFeb 28, 2022GOLD OA

Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response

BCBrandie C. TaylorJMJustin M. Balko

Vanderbilt University · Vanderbilt University Medical Center

PubMed
Indexed incrossrefdoajpubmed

Abstract

Immunotherapy has become a key therapeutic strategy in the treatment of many cancers. As a result, research efforts have been aimed at understanding mechanisms of resistance to immunotherapy and how anti-tumor immune response can be therapeutically enhanced. It has been shown that tumor cell recognition by the immune system plays a key role in effective response to T cell targeting therapies in patients. One mechanism by which tumor cells can avoid immunosurveillance is through the downregulation of Major Histocompatibility Complex I (MHC-I). Downregulation of MHC-I has been described as a mechanism of intrinsic and acquired resistance to immunotherapy in patients with cancer. Depending on the mechanism, the…

Citation impact

275
total citations
FWCI
21.55
Percentile
100%
References
135
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Downregulation and upregulation
  • Immunotherapy
  • Immunosurveillance
  • Major histocompatibility complex
  • Immune system
  • Immunology
  • MHC class I
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding