Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases

Abstract Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration and neurodegenerative diseases. Accumulating evidence shows multiple links between mitochondrial dysfunction and neuroinflammation. Mitochondrial-derived damage-associated molecular patterns (DAMPs) are recognized by immune receptors of microglia and aggravate neuroinflammation. On the other hand, inflammatory factors released by activated glial cells trigger an intracellular cascade, which regulates mitochondrial metabolism and function. The crosstalk between mitochondrial dysfunction and neuroinflammatory activation is a complex and dynamic process. There is strong evidence that mitochondrial dysfunction…

• NN
  National Natural Science Foundation of China

  Awards: 81671252, 81773768, 81730092
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions