paratextAfrican Journal of Traditional Complementary and Alternative MedicinesApr 21, 2016DIAMOND OA

African Journal of Traditional, Complementary and Alternative Medicines

SDSa-Caputo, Danubia C.DCDionello, Carla da F.FEFrederico, Eric Heleno F. F.PDPaineiras- Domingos, Laisa L.SCSousa-Gonçalves, Cintia Renata
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Abstract

BACKGROUND : The study was aimed at determining the anti-inflammatory activity of fractions and extracts obtained from Strychnos
\nspinosa leaves on a mediator of inflammation nitric oxide (NO).
\nMATERIALS AND METHODS : Leaves were extracted with acetone and separated into fractions with different polarities by solventsolvent
\nfractionation. The Griess assay was used to determine the nitric oxide (NO) inhibitory activity. Cellular toxicity was
\ndetermined by "using the MTT reduction assay".
\nRESULTS : With the exception of the ethyl acetate fraction which had an IC50 >750 μg/mL, all extracts and fractions had significant
\nnitric oxide-inhibitory activity. The most active being…

Citation impact

604
total citations
FWCI
—
Percentile
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References
14
Citations per year

Authors

9
  • SD
    Sa-Caputo, Danubia C.Corresponding
  • DC
    Dionello, Carla da F.
  • FE
    Frederico, Eric Heleno F. F.
  • PD
    Paineiras- Domingos, Laisa L.
  • SC
    Sousa-Gonçalves, Cintia Renata

Topics & keywords

Topics
Keywords
  • Traditional medicine
  • Medicine
UN Sustainable Development Goals
  • Zero hunger
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