Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis
Jiangnan University · State Key Laboratory of Food Science and Technology · +2 more institutions
Abstract
Gut microbial disturbance affects allergic diseases including asthma, atopic dermatitis (AD) via the aberrant immune response. Some Bifidobacterial species and strains have been reported to improve AD via modulating immune-microbe interactions in patients. However, the effective metabolites and mechanism of alleviating AD in bifidobacteria remain to be elucidated. This study aimed to explore the microbial metabolite and mechanism of Bifidobacterium longum to improve AD. Based on shotgun metagenomic sequencing and UHPLC Q-Exactive-MS targeted metabolic experiments in vitro and in vivo, we focused on tryptophan metabolism and indole derivatives, which are endogenous ligands for aryl hydrocarbon receptor (AHR).…
Citation impact
- FWCI
- 49.91
- Percentile
- 100%
- References
- 44
Authors
9- ZFZhifeng Fang
Jiangnan University, State Key Laboratory of Food Science and Technology
- TPTong Pan
Jiangnan University, State Key Laboratory of Food Science and Technology
- LLLingzhi Li
Jiangnan University, State Key Laboratory of Food Science and Technology
- HWHongchao Wang
Jiangnan University, State Key Laboratory of Food Science and Technology
- JZJinlin Zhu
Jiangnan University, State Key Laboratory of Food Science and Technology
Topics & keywords
- Bifidobacterium longum
- Biology
- Metabolite
- Aryl hydrocarbon receptor
- Immune system
- Gut flora
- Kynurenine
- Bifidobacterium