Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
Howard Hughes Medical Institute · Baylor College of Medicine · +58 more institutions
Abstract
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae , that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type–related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a…
Citation impact
- FWCI
- 156.88
- Percentile
- 100%
- References
- 60
Authors
158- HLHongjie LiCorresponding
Howard Hughes Medical Institute, Baylor College of Medicine, Stanford University
- JJJasper JanssensCorresponding
VIB-KU Leuven Center for Cancer Biology, VIB-KU Leuven Center for Brain & Disease Research
- MDMaxime De Waegeneer
VIB-KU Leuven Center for Cancer Biology, VIB-KU Leuven Center for Brain & Disease Research
- SSSai Saroja Kolluru
Chan Zuckerberg Initiative (United States), Stanford University
- KDKristofer Davie
VIB-KU Leuven Center for Brain & Disease Research
Topics & keywords
- Atlas (anatomy)
- On the fly
- Nucleus
- Biology
- Anatomy
- Cell biology
- Computer science
- Operating system