Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Houston Methodist · Baylor College of Medicine · +3 more institutions
Abstract
To express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T). Unlike chimeric antigen receptors (CARs), TCRs recognize HLA-presented peptides derived from proteins of all cellular compartments. The use of TCR T cells for adoptive cellular therapies (ACT) has gained increased attention, especially as efforts to treat solid cancers with ACTs have intensified. In this review, we describe the differing mechanisms of T cell antigen recognition and signal transduction mediated through CARs and TCRs. We describe the classes of cancer antigens recognized by current TCR T therapies and discuss both classical and emerging pre-clinical strategies for…
Citation impact
- FWCI
- 22.57
- Percentile
- 100%
- References
- 236
Authors
3- PSPaul ShaferCorresponding
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Texas Children's Hospital, Children's Cancer Center
- LKLauren Kelly
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Texas Children's Hospital, Children's Cancer Center
- VHValentina Hoyos
Houston Methodist, Baylor College of Medicine, Methodist Hospital, Texas Children's Hospital, Children's Cancer Center
Topics & keywords
- T-cell receptor
- Current (fluid)
- Cancer therapy
- Medicine
- Cancer research
- Computational biology
- Cancer
- Immunology
- Good health and well-being