The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial
University Medical Center Groningen · Universitätsklinikum Würzburg · +49 more institutions
Abstract
The sodium-glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but whether empagliflozin also improves clinical outcomes when initiated in patients who are hospitalized for acute heart failure is unknown. In this double-blind trial (EMPULSE; NCT04157751 ), 530 patients with a primary diagnosis of acute de novo or decompensated chronic heart failure regardless of left ventricular ejection fraction were randomly assigned to receive empagliflozin 10 mg once daily or placebo. Patients were randomized in-hospital when clinically stable (median time from hospital admission to randomization, 3 days) and were…
Citation impact
- FWCI
- 105.79
- Percentile
- 100%
- References
- 23
Authors
30- AAAdriaan A. VoorsCorresponding
University Medical Center Groningen
- CEChristiane E. Angermann
Universitätsklinikum Würzburg
- JRJohn R. Teerlink
San Francisco VA Medical Center, University of California, San Francisco
- SPSean P. Collins
Vanderbilt University Medical Center
- MKMikhail Kosiborod
The University of Sydney, Royal Prince Alfred Hospital, UNSW Sydney, The George Institute for Global Health, Saint Luke's Hospital, University of Missouri–Kansas City, University of Missouri
Topics & keywords
- Empagliflozin
- Medicine
- Heart failure
- Ejection fraction
- Clinical endpoint
- Placebo
- Internal medicine
- Randomized controlled trial
- Good health and well-being
Funding
- UDU.S. Department of Veterans Affairs
- BIBoehringer Ingelheim
- ELEli Lilly and Company
- VUVanderbilt University
- UOUniversity of Missouri
- UDUniversité de Lorraine
- UOUniversity of Missouri-Kansas City
- VUVanderbilt University Medical Center
- SLSaint Luke's Health System
- NUNational University of Singapore
- UHUniversität Heidelberg
- INInstitut National de la Santé et de la Recherche Médicale
- RGRijksuniversiteit Groningen
- UOUniversity of New South Wales
- CMCapital Medical University
- KLKU Leuven
- UMUniversitair Medisch Centrum Groningen
- UŁUniwersytet Łódzki
- SUSahlgrenska Universitetssjukhuset
- GUGöteborgs Universitet
- UDUniversidade do Porto
- MUMasarykova Univerzita
- NUNational University Health System
- AUAkershus Universitetssykehus
- MRMax Rady College of Medicine, University of Manitoba
- SOSchool of Medicine, University of Missouri
- DCDuke Clinical Research Institute