reviewSignal Transduction and Targeted TherapyMar 21, 2022GOLD OA

The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

YHYuyi HanJYJianxin YangJFJiankai FangYZYipeng ZhouECEleonora Candi

Jiangnan University · University of Rome Tor Vergata · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-renewal potentials. MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases, due to the potent immunoregulatory functions of MSCs. An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions. Growth factors, cytokines, chemokines, extracellular matrix components, and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms. These secretory factors contribute to immune modulation, tissue remodeling, and cellular homeostasis during regeneration. In this review, we summarize and…

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679
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Authors

9

Topics & keywords

Topics
Keywords
  • Mesenchymal stem cell
  • Paracrine signalling
  • Immune system
  • Cell biology
  • Stem cell
  • Biology
  • Stromal cell
  • Chemokine
UN Sustainable Development Goals
  • Good health and well-being
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