reviewAdvanced ScienceMar 25, 2022GOLD OA

Exosome Processing and Characterization Approaches for Research and Technology Development

JJJames J. LaiZLZoe L. ChauSCSheng‐You ChenJJJohn J. HillKVKatalin V. Korpany

University of Washington · National Tsing Hua University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high-quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well-characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization…

Citation impact

560
total citations
FWCI
42.79
Percentile
100%
References
364
Citations per year

Authors

12

Topics & keywords

Topics
Keywords
  • Exosome
  • Microvesicles
  • Extracellular vesicles
  • Computational biology
  • Workflow
  • Extracellular vesicle
  • Nanotechnology
  • Computer science
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
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