articleNature GeneticsMar 31, 2022HYBRID OA

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

AOAysu OkbayYWYeda WuNWNancy WangHJHariharan JayashankarMBMichael Bennett

Vrije Universiteit Amsterdam · The University of Queensland · +136 more institutions

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Abstract

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance…

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Topics & keywords

Topics
Keywords
  • Genome-wide association study
  • Biology
  • Single-nucleotide polymorphism
  • Genetics
  • Genetic association
  • Genome
  • Multifactorial Inheritance
  • Genotype
UN Sustainable Development Goals
  • Quality Education
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