Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing
China Pharmaceutical University · Nanjing Drum Tower Hospital · +2 more institutions
Abstract
Wound dressing with the capacities of antioxidation, antiinflammation, and efficient angiogenesis induction is expected for effectively promoting wound healing. Herein, a novel core-shell hyaluronic acid (HA) microneedle (MN) patch with ferrum-mesenchymal stem cell-derived artificial nanovesicles (Fe-MSC-NVs) and polydopamine nanoparticles (PDA NPs) encapsulated in the needle tips is presented for wound healing. Fe-MSC-NVs containing multifunctional therapeutic cytokines are encapsulated in the inner HA core of the MN tips for accelerating angiogenesis. The PDA NPs are encapsulated in the outer methacrylated hyaluronic acid (HAMA) shell of the MN tips to overcome the adverse impacts from reactive oxygen…
Citation impact
- FWCI
- 32.23
- Percentile
- 100%
- References
- 41
Authors
8- WMWenjuan Ma
China Pharmaceutical University, Nanjing Drum Tower Hospital
- XZXiaoxuan Zhang
State Key Laboratory of Digital Medical Engineering, Southeast University
- YLYuxiao Liu
State Key Laboratory of Digital Medical Engineering, Southeast University
- LFLu Fan
State Key Laboratory of Digital Medical Engineering, Southeast University
- JGJingjing Gan
Nanjing Drum Tower Hospital
Topics & keywords
- Hyaluronic acid
- Wound healing
- Angiogenesis
- Mesenchymal stem cell
- Reactive oxygen species
- Inflammation
- Scars
- Oxidative stress
- Life in Land