reviewCellular and Molecular Life SciencesMar 1, 2022HYBRID OA

Type I interferon-mediated tumor immunity and its role in immunotherapy

RYRenren YuBZBo ZhuDCDegao Chen

Army Medical University · Wenzhou Medical University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Immune checkpoint blockade (ICB) therapies have achieved remarkable clinical responses in patients with many different types of cancer; however, most patients who receive ICB monotherapy fail to achieve long-term responses, and some tumors become immunotherapy-resistant and even hyperprogressive. Type I interferons (IFNs) have been demonstrated to inhibit tumor growth directly and indirectly by acting upon tumor and immune cells, respectively. Furthermore, accumulating evidence indicates that endo- and exogenously enhancing type I IFNs have a synergistic effect on anti-tumor immunity. Therefore, clinical trials studying new treatment strategies that combine type I IFN inducers with ICB are currently in…

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297
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100%
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Authors

3

Topics & keywords

Topics
Keywords
  • Immunotherapy
  • Interferon
  • Immunity
  • Immunology
  • Biology
  • Cancer research
  • Immune system
UN Sustainable Development Goals
  • Good health and well-being
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