Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications
National Interuniversity Consortium of Materials Science and Technology · University of Palermo
Abstract
Synthetic biopolymers are effective cues to replace damaged tissue in the tissue engineering (TE) field, both for in vitro and in vivo application. Among them, poly-l-lactic acid (PLLA) has been highlighted as a biomaterial with tunable mechanical properties and biodegradability that allows for the fabrication of porous scaffolds with different micro/nanostructures via various approaches. In this review, we discuss the structure of PLLA, its main properties, and the most recent advances in overcoming its hydrophobic, synthetic nature, which limits biological signaling and protein absorption. With this aim, PLLA-based scaffolds can be exposed to surface modification or combined with other biomaterials, such as…
Citation impact
- FWCI
- 18.55
- Percentile
- 100%
- References
- 190
Authors
4- ECElisa Capuana
National Interuniversity Consortium of Materials Science and Technology, University of Palermo
- FLFrancesco LoprestiCorresponding
National Interuniversity Consortium of Materials Science and Technology, University of Palermo
- MCManuela Ceraulo
National Interuniversity Consortium of Materials Science and Technology, University of Palermo
- VLVincenzo La Carrubba
National Interuniversity Consortium of Materials Science and Technology, University of Palermo
Topics & keywords
- Biomaterial
- Materials science
- Scaffold
- Tissue engineering
- Nanotechnology
- Electrospinning
- Regenerative medicine
- Surface modification