articleNature CommunicationsJan 10, 2022GOLD OA

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

HSHanbing SongHWH WeinsteinPAPaul AllegakoenMHMarc H. WadsworthJXJamie Xie

University of California, San Francisco · UCSF Helen Diller Family Comprehensive Cancer Center · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organoids from localized prostate cancer patients. We uncover heterogeneous cellular states in prostate epithelial cells marked by high androgen signaling states that are enriched in prostate cancer and identify a population of tumor-associated club cells that may be associated with prostate carcinogenesis. ERG-negative tumor cells, compared to ERG-positive cells, demonstrate shared heterogeneity with surrounding…

Citation impact

268
total citations
FWCI
25.06
Percentile
100%
References
111
Citations per year

Authors

15

Topics & keywords

Topics
Keywords
  • Prostate cancer
  • Prostate
  • Carcinogenesis
  • Tumor microenvironment
  • Cancer research
  • Chromoplexy
  • Biology
  • Cell
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding