Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis
Shanghai Jiao Tong University · Shanghai Ninth People's Hospital · +2 more institutions
Abstract
Diabetic osteoporosis (DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1 (HO-1) expression was notably upregulated in ferroptotic osteocytes. Further…
Citation impact
- FWCI
- 39.67
- Percentile
- 100%
- References
- 50
Authors
13- YYYiqi Yang
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- YLYixuan Lin
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- MWMinqi Wang
Shanghai Jiao Tong University, Renji Hospital
- KYKai Yuan
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
- QWQishan Wang
Shanghai Jiao Tong University, Shanghai Ninth People's Hospital
Topics & keywords
- Osteocyte
- Downregulation and upregulation
- Cell biology
- Chemistry
- Programmed cell death
- Lipid peroxidation
- Osteoporosis
- Cancer research
- Good health and well-being