reviewChemical ReviewsMar 14, 2022HYBRID OA

Nitrogen-Centered Radicals in Functionalization of sp 2 Systems: Generation, Reactivity, and Applications in Synthesis

CPCassie PratleySFSabine FennerJAJohn A. Murphy

University of Strathclyde · Age UK

PubMed
Indexed incrossrefpubmed

Abstract

Moieties without prefunctionalization, allowing for faster and more streamlined synthesis. This Review addresses the generation, reactivity, and application of NCRs, including, but not limited to, iminyl, aminyl, amidyl, and aminium species. Contributions from early discovery up to the most recent examples have been highlighted, covering radical initiation, thermolysis, photolysis, and, more recently, photoredox catalysis. Radical-mediated intermolecular amination of (hetero)arenes can occur with a variety of complex amine precursors, generating aniline derivatives, an important class of structures for drug discovery and development. Functionalization of olefins is achievable in high anti-Markovnikov…

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385
total citations
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38.49
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100%
References
402
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Authors

3

Topics & keywords

Topics
Keywords
  • Chemistry
  • Amination
  • Radical
  • Reactivity (psychology)
  • Surface modification
  • Photoredox catalysis
  • Combinatorial chemistry
  • Organic synthesis
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