The blood-brain barrier in aging and neurodegeneration
University College Cork · APC Microbiome Institute
Abstract
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the brain. This barrier, however, breaks down with age and further disruption is a hallmark of many age-related disorders. Several drugs have been explored, thus far, to protect or restore BBB function. With the recent connection between the BBB and gut microbiota, microbial-derived metabolites have been explored for their capabilities to protect and restore BBB physiology. This review, will focus on the vital components that make up the BBB, dissect levels of…
Citation impact
- FWCI
- 48.06
- Percentile
- 100%
- References
- 220
Authors
5- EGEmily G. KnoxCorresponding
University College Cork, APC Microbiome Institute
- MRMaría R. Aburto
University College Cork, APC Microbiome Institute
- GCGerard Clarke
University College Cork, APC Microbiome Institute
- JFJohn F. Cryan
University College Cork, APC Microbiome Institute
- CMCaitríona M. O’Driscoll
University College Cork
Topics & keywords
- Neurodegeneration
- Neuroscience
- Blood–brain barrier
- Brain aging
- Psychology
- Medicine
- Central nervous system
- Disease
- Good health and well-being