Lipid alterations in chronic liver disease and liver cancer

Paul, Bichitra; Lewińska, Monika; Andersen, Jesper B.

doi:10.1016/j.jhepr.2022.100479

reviewJHEP ReportsMar 25, 2022GOLD OA

Lipid alterations in chronic liver disease and liver cancer

BPBichitra Paul MLMonika Lewińska JBJesper B. Andersen

University of Copenhagen

PubMed

Indexed incrossrefdoajpubmed

Abstract

Lipids are a complex and diverse group of molecules with crucial roles in many physiological processes, as well as in the onset, progression, and maintenance of cancers. Fatty acids and cholesterol are the building blocks of lipids, orchestrating these crucial metabolic processes. In the liver, lipid alterations are prevalent as a cause and consequence of chronic hepatitis B and C virus infections, alcoholic hepatitis, and non-alcoholic fatty liver disease and steatohepatitis. Recent developments in lipidomics have also revealed that dynamic changes in triacylglycerols, phospholipids, sphingolipids, ceramides, fatty acids, and cholesterol are involved in the development and progression of primary liver cancer.…

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305

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Percentile: 100%
References: 330

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Authors

3

Topics & keywords

Topics

Keywords

Lipidome
Lipidomics
Steatohepatitis
Fatty liver
Sphingolipid
Lipid metabolism
Biology
Liver cancer

UN Sustainable Development Goals

Good health and well-being

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