Notch signaling pathway: architecture, disease, and therapeutics
Tongji Hospital · Huazhong University of Science and Technology
Abstract
The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the development and homeostasis of multiple tissues and organs, the aberration of which results in cancerous and noncancerous diseases. However, recent studies indicate that the outcomes of NOTCH signaling are changeable and highly dependent on context. In terms of cancers, NOTCH signaling can both promote and inhibit tumor development in various types of cancer. The overall performance of NOTCH-targeted…
Citation impact
- FWCI
- 130.98
- Percentile
- 100%
- References
- 707
Authors
7- BZBinghan ZhouCorresponding
Tongji Hospital, Huazhong University of Science and Technology
- WLWanling Lin
Tongji Hospital, Huazhong University of Science and Technology
- YLYaling Long
Tongji Hospital, Huazhong University of Science and Technology
- YYYunkai Yang
Tongji Hospital, Huazhong University of Science and Technology
- HZHuan Zhang
Tongji Hospital, Huazhong University of Science and Technology
Topics & keywords
- Notch signaling pathway
- Cyclin-dependent kinase 8
- Hes3 signaling axis
- Biology
- Signal transduction
- Tumor microenvironment
- Cancer research
- Context (archaeology)
- Good health and well-being