Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study

Lauring, Adam S.; Tenforde, Mark W.; Chappell, James D.; Gaglani, Manjusha; Ginde, Adit A.; McNeal, Tresa; Ghamande, Shekhar; Douin, David J.; Talbot, H. Keipp; Casey, Jonathan D.; Mohr, Nicholas M.; Zepeski, Anne; Shapiro, Nathan I.; Gibbs, Kevin W.; Files, D. Clark; Hager, David N.; Shehu, Arber; Prekker, Matthew E.; Erickson, Heidi L.; Exline, Matthew C.; Gong, Michelle N.; Mohamed, Amira; Johnson, Nicholas J.; Srinivasan, Vasisht; Steingrub, Jay S.; Peltan, Ithan D.; Brown, Samuel M.; Martin, Emily T.; Monto, Arnold S.; Khan, Akram; Hough, Catherine L.; Busse, Laurence W.; Lohuis, Caitlin C. ten; Duggal, Abhijit; Wilson, Jennifer G.; Gordon, Alexandra June; Qadir, Nida; Chang, Steven Y.; Mallow, Christopher; Rivas, Carolina; Babcock, Hilary M.; Kwon, Jennie H.; Halasa, Natasha; Grijalva, Carlos G.; Rice, Todd W.; Stubblefield, William B.; Baughman, Adrienne; Womack, Kelsey N.; Rhoads, Jillian P.; Lindsell, Christopher J.; Hart, Kimberly W.; Zhu, Yuwei; Adams, Katherine; Schrag, Stephanie J.; Olson, Samantha M.; Kobayashi, Miwako; Verani, Jennifer R.; Patel, Manish M.; Self, Wesley H.

doi:10.1136/bmj-2021-069761

articleBMJMar 9, 2022BRONZE OA

Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study

ASAdam S. Lauring MWMark W. Tenforde JDJames D. Chappell MGManjusha Gaglani AAAdit A. Ginde

University of Michigan · CDC Foundation · +24 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Objectives

To characterize the clinical severity of covid-19 associated with the alpha, delta, and omicron SARS-CoV-2 variants among adults admitted to hospital and to compare the effectiveness of mRNA vaccines to prevent hospital admissions related to each variant.

Design

Case-control study.

Citation impact

678

total citations

FWCI: 66.53
Percentile: 100%
References: 29

Citations per year

Authors

59

Topics & keywords

Topics

Keywords

Medicine
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Odds ratio
Confidence interval
Observational study
Internal medicine
2019-20 coronavirus outbreak

UN Sustainable Development Goals

Good health and well-being

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