Role of Cholinergic Signaling in Alzheimer’s Disease
Nanchang University · Fuzhou University
Indexed incrossrefdoajpubmed
Abstract
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive and commonly diagnosed neurodegenerative disease, is characterized by memory and cognitive decline and behavioral disorders. The pathogenesis of AD is complex and remains unclear, being affected by various factors. The cholinergic hypothesis is the earliest theory about the pathogenesis of AD. Cholinergic atrophy and cognitive decline are accelerated in age-related neurodegenerative diseases such as AD. In addition, abnormal central cholinergic changes can also induce abnormal phosphorylation of ttau protein, nerve cell…
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774
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- 100%
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Authors
4Topics & keywords
Topics
Keywords
- Cholinergic
- Neuroscience
- Pathogenesis
- Cholinergic neuron
- Acetylcholine
- Disease
- Medicine
- Neurotransmitter
UN Sustainable Development Goals
- Good health and well-being
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