IntegronFinder 2.0: Identification and Analysis of Integrons across Bacteria, with a Focus on Antibiotic Resistance in Klebsiella
Institut Pasteur · Université Paris Cité · +5 more institutions
Abstract
Integrons are flexible gene-exchanging platforms that contain multiple cassettes encoding accessory genes whose order is shuffled by a specific integrase. Integrons embedded within mobile genetic elements often contain multiple antibiotic resistance genes that they spread among nosocomial pathogens and contribute to the current antibiotic resistance crisis. However, most integrons are presumably sedentary and encode a much broader diversity of functions. IntegronFinder is a widely used software to identify novel integrons in bacterial genomes, but has aged and lacks some useful functionalities to handle very large datasets of draft genomes or metagenomes. Here, we present IntegronFinder version 2. We have…
Citation impact
- FWCI
- 20.62
- Percentile
- 100%
- References
- 64
Authors
6- BNBertrand Néron
Institut Pasteur, Université Paris Cité
- ELEloi Littner
Centre National de la Recherche Scientifique, Institut Pasteur, Université Sorbonne Nouvelle, Université Paris Cité, Sorbonne Université
- MHMatthieu Haudiquet
Centre National de la Recherche Scientifique, Institut Pasteur, Université Paris Cité
- APAmandine Perrin
Centre National de la Recherche Scientifique, Institut Pasteur, Université Sorbonne Nouvelle, Université Paris Cité, Sorbonne Université
- JCJean CuryCorresponding
Centre National de la Recherche Scientifique, Institut national de recherche en sciences et technologies du numérique, Institut Pasteur, Université Paris Cité, Université Paris-Saclay
Topics & keywords
- Klebsiella
- Antibiotic resistance
- Microbiology
- Identification (biology)
- Antibiotics
- Bacteria
- Biology
- Genetics