GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing
Union Hospital · Huazhong University of Science and Technology · +3 more institutions
Abstract
Clinical work and research on diabetic wound repair remain challenging globally. Although various conventional wound dressings have been continuously developed, the efficacy is unsatisfactory. The effect of drug delivery is limited by the depth of penetration. The sustained release of biomolecules from biological wound dressings is a promising treatment approach to wound healing. An assortment of cell-derived exosomes (exos) have been proved to be instrumental in tissue regeneration, and researchers are dedicated to developing biomolecules carriers with unique properties. Herein, we reported a methacrylate gelatin (GelMA) microneedles (MNs) patch to achieve transdermal and controlled release of exos and…
Citation impact
- FWCI
- 25.66
- Percentile
- 100%
- References
- 50
Authors
12- MYMeng YuanCorresponding
Union Hospital, Huazhong University of Science and Technology
- KLKun Liu
Wuhan University of Technology
- TJTao Jiang
Union Hospital, Huazhong University of Science and Technology
- SLShengbo Li
Union Hospital, Huazhong University of Science and Technology
- JCJing Chen
Union Hospital, Huazhong University of Science and Technology
Topics & keywords
- Wound healing
- Transdermal
- Biomedical engineering
- Drug delivery
- Chemistry
- Angiogenesis
- Regeneration (biology)
- Self-healing hydrogels
- Good health and well-being