Strategies for enhancing cancer chemodynamic therapy performance

In tumor microenvironment (TME) to produce cytotoxic hydroxyl radicals (•OH) via Fenton or Fenton-like reactions. While possessing advantages such as tumor specificity, no need of external stimuli, and low side effects, practical applications of CDT are still impeded owing to the heterogeneity, complexity, and reductive environment of TME. Over the past couple of years, strategies to enhance CDT for efficient tumor regression are in rapid development in synergy with the growth of nanomedicine. In this review, we initially outline the fundamental understanding of Fenton and Fenton-like reactions and their relationship with CDT. Subsequently, the development in the design of nanosystems for CDT is highlighted in…

• NR
  National Research Foundation
• AF
  Agency for Science, Technology and Research

  Award: A20E5c0081
• NR
  National Research Foundation Singapore

  Awards: NRF-NRFI2018-03, NRFI2018-03