reviewFrontiers in OncologyMar 22, 2022GOLD OA

pH-Responsive Polymer Nanomaterials for Tumor Therapy

Jilin University · Chinese Academy of Sciences · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery systems can be constructed for targeted drug delivery to tumor sites. Among these, the pH is frequently utilized, owing to the pH of the tumor microenvironment being lower than that of blood and healthy tissues. pH-responsive polymer carriers can improve the efficiency of drug delivery in vivo , allow targeted drug delivery, and reduce adverse drug reactions, enabling multifunctional and personalized treatment. pH-responsive polymers have gained increasing…

Citation impact

249
total citations
FWCI
16.59
Percentile
100%
References
210
Citations per year

Authors

4

Topics & keywords

Keywords
  • Drug delivery
  • Cancer therapy
  • Nanotechnology
  • Tumor microenvironment
  • Drug
  • Targeted drug delivery
  • Nanomaterials
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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